Million Dollar Ideas ?Suggest an invention

      wondersite@gmail.comTop Tech: DESCENT
11/11/2013 06:04 AM CST

Top Technology is an Armed with Science series that highlights the latest and greatest federal laboratory inventions, technology and achievements. Want to suggest an invention? Email us at science@dma.mil Technology: DESCENT Modeling Technology Agency: Army Research Laboratory The Army Research Laboratory (ARL) has created software designed to determine the worst case scenario when it comes to […]

wondersite@gmail.comThe Department of Defense is pushing to develop and deploy renewable energy

STEM CELL RESEARCH

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Stem Cells: The Solution to Living Over 100 Years? - DUJS Online

dujs.dartmouth.edu/.../stem-cells-the-solution-to-live-more-than-100-yea...‎

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Jan 29, 2013 - ... these treatments have yet to increase lifespan over a hundred years. ... In human terms, that would be the equivalent of an 80-year-old living to be 200. ... studied the effects of injecting muscle-derived stem/progenitor cells  ...

How Engineered Stem Cells May Enable Youthful ... - Life Extension

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Related articlesdoctors to inject progenitor cells that will regenerate every tissue in your body ... not sufficiently extend human life expectancy to meet the objectives of those who   ...

Mesenchymal Stem Cells Extend Median Life Span in Mice

Brain Control Research( Do we need new treaties, a new Geneva Convention in many new such technologies?)

wondersite@gmail.comWritten on September 1, 2010 at 1:13 pm by Armed with Science

Remote Control of Brain Activity Using UltrasoundFiled under Life Sciences, Physical Sciences, Technology {67 comments}

Dr. William J. Tyler is an

Assistant Professor in the School of Life Sciences at Arizona State University, is a co-founder and the CSO of SynSonix, Inc., and a member of the 2010 DARPA Young Faculty Award class.Every single aspect of human sensation, perception, emotion, and behavior is regulated by brain activity. Thus, having the ability to stimulate brain function is a powerful technology.
Recent advances in neurotechnology have shown that brain stimulation is capable of treating neurological diseases and brain injury, as well as serving platforms around which brain-computer interfaces can be built for various purposes. Several limitations however still pose significant challenges to implementing traditional brain stimulation methods for treating diseases and controlling information processing in brain circuits.
For example, deep-brain stimulating (DBS) electrodes used to treat movement disorders such as Parkinson’s disease require neurosurgery in order to implant electrodes and batteries into patients. Transcranial magnetic stimulation (TMS) used to treat drug-resistant depression and other disorders do not require surgery, but have a low spatial resolution of approximately one centimeter and cannot stimulate deep brain circuits where many diseased circuits reside.

These illustrations show the surgical invasiveness of deep-brain stimulating electrodes (left) and depict the low spatial resolutions conferred by transcranial magnetic stimulation (right). (Image: Tyler Lab)

To overcome the above limitations, my
laboratory has engineered a novel technology which implements transcranial pulsed ultrasound to remotely and directly stimulate brain circuits without requiring surgery. Further, we have shown this ultrasonic neuromodulation approach confers a spatial resolution approximately five times greater than TMS and can exert its effects upon subcortical brain circuits deep within the brain.A portion of our initial work has been supported by the
U.S. Army Research, Development and Engineering Command (RDECOM) Army Research Laboratory (ARL) where we have been working to develop methods for encoding sensory data onto the cortex using pulsed ultrasound.Through a recent grant made by the
Defense Advanced Research Projects Agency (DARPA) Young Faculty Award Program, our research will begin undergoing the next phases of research and development aimed towards engineering future applications using this neurotechnology for our country’s warfighters. Here, we will continue exploring the influence of ultrasound on brain function and begin using transducer phased arrays to examine the influence of focused ultrasound on intact brain circuits. We will also be investigating the use of capacitive micromachined ultrasonic transducers (CMUTs) for use in brain stimulation. Finally, to improve upon spatial resolution, we will examine the use of acoustic metamaterials and hyperlenses to study how subdiffraction limited ultrasound influences brain wave activity patterns.How can this technology be used to provide our nation’s Warfighters with strategic advantages? We have developed working and conceptual prototypes in which ballistic helmets can be fitted with ultrasound transducers and microcontroller devices to illustrate potential applications as shown below. We look forward to developing a close working relationship with
DARPA and other Department of Defense and U.S. Intelligence Communities to bring some of these applications to fruition over the coming years depending on the most pressing needs of our country’s defense industries.

Above illustrations show a ballistic helmet fitted with four ultrasound transducers (left) and another functional prototype for achieving human brain stimulation using a single element transducer (bottom-right), as well as a list of potential applications relevant to the defense industry. (Image: Tyler Lab)

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Scholarly articles for science stem cell changing human culture

wondersite@gmail.com Scholarly articles for science stem cell changing human culture

U.S. Department of Defense Armed with Science UpdateU.S. Department of Defense Armed with Science Update

wondersite@gmail.comMissile Defense System Intercepts Target in Test

Medal of Honor Ceremony for Army Captain William Swenson
As Delivered by Secretary of Defense Chuck Hagel, Pentagon Auditorium, Wednesday, October 16, 2013
Good afternoon.
Secretary McHugh, General Odierno, Sergeant Major Chandler, Chairman Dempsey, ladies and gentlemen, the men and women who serve our country today in uniform, the civilian employees who support our men and women in uniform, and in particular our special guests here this afternoon, who have been recognized, and our most honored guest, Captain Swenson and his family.
I have a quite elegant speech, of course. But I will dispense with these eloquent words.  And I'm going to make a couple of comments I hope that will add to the true eloquence of the chiefs and secretary's comments.
I could not improve on, or I don't mean to duplicate what they said, what President Obama said yesterday, what everyone in this room knows about this very special individual.
Let me add my thoughts this way.  Many important words have been said about Will Swenson, appropriately so, over the last few days.  One particular point that President Obama made yesterday was that at a time in our country when  we need more unifying dimensions and dynamics to remind us who we are, yes, as a great nation, but, even more importantly, as a good people.  The Will Swenson story does that.  It does remind us who we are -- sacrifice, service, going beyond your own personal ambitions, your own personal interests, and serving the interests of others first.
I don't know a more complete picture that could be presented or example noted of that selflessness than the story of Will Swenson and those who have gone before, and every man and women in the history of this great republic who have given so much of themselves, and the people in this room and all over the world who continue to do that.
Will, you mean an awful lot to a lot of people, but your biggest contribution probably will come later.  And that is the role model that you have already projected, not just for men and women in uniform, but the next generations behind you.  We all recognize as parents, as individuals who have any responsibility for positions in life, that that is our biggest, most significant responsibility, to improve upon the inheritance that we were each given, the blessings and the good things.  We know about bad things.
But that's not our role.  Our role is to improve, make it better, inspire, uplift our people, our families, our country and the world.  And as President Obama noted yesterday, the Will Swenson story is a great reminder of those responsibilities and how we can do it with dignity, with eloquence, with never asking anything in return.
I want to also note something that was said here today, mentioned by the chief, mentioned by the secretary.  Yes, Will Swenson proved his valor on the battlefield.  It is well documented.  It should be well documented.  But he also did something else that represented tremendous courage and integrity.  And I've always thought the two indispensable elements of anyone's life are courage and character.  And if we're without those in some measure, it's a pretty hallow existence.
He questioned -- he dared to question the institution that he was faithful to and loyal to.  Mistakes were made, in his case.  Now, that's courage and that's integrity and that's character.  As the institution itself reflected on that same courage and integrity institutionally, the institution, the United States Army, corrected the mistake.  They went back and acknowledged a mistake was made and they fixed it.
Another great dimension of our republic, of our people, we have an inherent capability to self-correct.  Free people have that capability if they have the will and the courage to self-correct.  And we all do in our own personal lives.  Institutions don't always.  Eventually they will be forced to.  In this case, the United States Army was not forced to.  It did self-correct.  It was a wrong.  They corrected it.  They fixed it.
We're sorry that you and your family had to endure through that, but you did and you handled it right.  And I think that deserves a tremendous amount of attention and credit.  We celebrate you today, Will.  We celebrate your family.  We celebrate your very brave colleagues who have been recognized, those who didn't make it back, their families today.  But we celebrate all the good things about our country today because of you.  And we're grateful.
May God bless you and your family, Will.  Thank you.  Thank you.

stem cell research

City College Of San Francisco Carin Zimmerman Bridges Stem Cell Training Enhancement Program $2,454,307

City College Of San Francisco	Carin Zimmerman	Bridges	Stem Cell Training Enhancement Program	$2,454,307
Berkeley City College	Barbara Des Rochers	Bridges	Specialty in Stem Cell Biology	$2,450,257
Beckman Research Institute of City of Hope	Larry Couture	Tools and Technologies I	Development of Suspension Adaptation, Scale-up cGMP Banking and Cell Characterization Technologies for hESC Lines	$882,929
University of California, San Diego	Sylvia Evans	SEED Grant	Specification of Ventricular Myocyte and Pacemaker Lineages Utilizing Human Embryonic Stem Cells	$609,999
University of California, Berkeley	Randy Schekman	Training Grant I-1	Human Stem Cell Training at UC Berkeley and Childrens Hospital of Oakland	$2,529,810
ViaCyte, Inc.	Allan Robins	Disease Team Research I	Cell Therapy for Diabetes	$22,999,937
University of California, Santa Barbara	Carol Pasternack	Creativity Awards	Research Mentorship Program-Immersing High School Students in College Research	$223,080
The Salk Institute for Biological Studies	Juan Carlos Izpisua Belmonte	Training Grant I-3	Training in the Biology of Human Enbryonic Stem Cells and Emerging Technologies	$1,496,880
Stanford University	Howard Chang	New Faculty I	Noncoding RNAs in Cell Fate Determination	$3,203,926
University of California, San Francisco	Su Guo	SEED Grant	Identifying small molecules that stimulate the differentiation of hESCs into dopamine-producing neurons	$564,309
Stanford University	Ricardo Dolmetsch	Tools and Technologies II	Development of small molecule screens for autism using patient-derived iPS cells	$1,884,808
University of California, Los Angeles	William Lowry	Basic Biology III	Molecular determinants of accurate differentiation from human pluripotent stem cells	$1,354,230
Stanford University	Susan McConnell	Basic Biology I	Identification and characterization of human ES-derived DA neuronal subtypes	$1,407,076
University of California, Davis	Mehrdad Abedi	Disease Team Therapy Planning I	RUNNING TITLE: Stem Cell Gene Therapy for HIV in AIDS Lymphoma Patients	$74,195
University of California, Los Angeles	Siavash Kurdistani	New Faculty I	Epigenetics in cancer stem cell initiation and clinical outcome prediction	$3,238,450
University of California, Santa Cruz	Bin Chen	SEED Grant	In vitro differentiation of hESCs into corticospinal motor neurons	$500,000
Sanford Consortium for Regenerative Medicine	Edward Holmes	Major Facilities	No Title	$43,000,000
University of California, Berkeley	Ellen Robey	Research Training II	Interdisciplinary Training in Stem Cell Biology, Engineering and Medicine	$6,902,189
The J. David Gladstone Institutes	Steven Finkbeiner	Basic Biology IV	Common molecular mechanisms in neurodegenerative diseases using patient based iPSC neurons	$1,506,420
Stanford University	Aaron Hsueh	Basic Biology II	Maturation of Human Oocytes for SCNT and Embryonic Stem Cell Derivation	$1,432,197
University of California, Los Angeles	Stanley Nelson	Disease Team Therapy Planning I	Combination therapy to Enhance Antisense Mediated Exon Skipping for Duchenne Muscular Dystrophy	$86,414
Stanford University	Ching-Pin Chang	New Faculty II	VEGF signaling in adventitial stem cells in vascular physiology and disease	$3,330,931
The J. David Gladstone Institutes	Warner Greene	SEED Grant	The APOBEC3 Gene Family as Guardians of Genome Stability in Human Embryonic Stem Cells	$777,467
Stanford University	Thomas Rando	Disease Team Planning	Stem Cell Therapy for Muscular Dystrophy	$52,650
Stanford University	Renee Reijo Pera	Shared Labs	Center for Human Embryonic Stem Cell Research and Education	$5,819,047
Stanford University	Alexander Dunn	Basic Biology IV	Role of mechanical signaling in stem cell self-renewal and differentiation	$1,064,224
Stanford University	Michael Clarke	Basic Biology III	USP16 controls stem cell number: implications for Down Syndrome	$1,425,600
University of California, Davis	Alice Tarantal	Early Translational I	In Utero Model to Assess the Fate of Transplanted Human Cells for Translational Research and Pediatric Therapies	$4,214,592
University of California, San Francisco	Andrew Leavitt	Comprehensive Grant	Understanding hESC-based Hematopoiesis for Therapeutic Benefit	$2,566,702
University of California, Santa Cruz	David Feldheim	SEED Grant	Assessing the role of Eph/ephrin signaling in hESC growth and differentiation	$499,999
University of Southern California	Chrysostomos Nikias	Major Facilities	No Title	$26,972,500
University of California, Irvine	Leslie Thompson	New Cell Lines	New Cell Lines for Huntington's Disease	$1,369,800
California State University, San Marcos	Bianca Mothe	Bridges	CIRM Bridges to the Stem Cell Research Training Grant	$3,613,311
Scripps Research Institute	Peter Schultz	Early Translational II	Cartilage Regeneration by the Chondrogenic Small Molecule PRO1 during Osteoarthritis	$6,792,660
Stanford University	Robert Negrin	Transplantation Immunology	Regulatory T cell induced tolerance to ESC transplantation	$1,427,980
University of California, San Francisco	Arnold Kriegstein	Comprehensive Grant	Derivation of Inhibitory Nerve Cells from Human Embryonic Stem Cells	$2,507,223
Stanford University	Renee Reijo Pera	Comprehensive Grant	Human oocyte development for genetic, pharmacological and reprogramming applications	$2,469,104
University of California, San Diego	Steve Dowdy	Tools and Technologies I	TAT Cell-Permeable Protein Delivery of siRNAs for Epigenetic Programming of Human Pluripotent and Adult Stem Cells	$925,200
University of California, San Diego	Binhai Zheng	SEED Grant	Genetic manipulation of human embryonic stem cells and its application in studying CNS development and repair	$642,361
University of California, Irvine	Peter Bryant	Training Grant I-1	Stem Cell Research Training Grant	$2,039,845
Cedars-Sinai Medical Center	Eduardo Marbán	Disease Team Research I	Autologous cardiac-derived cells for advanced ischemic cardiomyopathy	$5,560,232
Stanford University	Paul Utz	Creativity Awards	[REDACTED] Program: Stem Cell & Developmental Biology Research Internships	$288,750
Scripps Research Institute	Peter Schultz	Early Translational III	Targeting Stem Cells to Enhance Remyelination in the Treatment of Multiple Sclerosis	$4,327,175
University of California, Santa Cruz	Camilla Forsberg	New Faculty I	Mechanisms of Stem Cell Fate Decisions	$2,330,111
University of Southern California	David Hinton	SEED Grant	Therapeutic potential of Retinal Pigment Epithelial cell lines derived from hES cells for retinal degeneration.	$684,322
Stanford University	Marius Wernig	Tools and Technologies II	Cellular tools to study brain diseases affecting synaptic transmission	$1,906,494
University of California, Los Angeles	Shuo Lin	Basic Biology III	Etsrp/ER71 mediated stem cell differentiation into vascular lineage	$1,382,400
University of California, San Diego	Eugene Yeo	Basic Biology I	RNA Binding Protein-mediated Post-transcriptional Networks Regulating HPSC Pluripotency	$1,376,802
Stanford University	Judith Shizuru	Disease Team Therapy Planning I	A monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants	$109,676
University of California, Los Angeles	Hanna Mikkola	New Faculty I	Mechanisms of Hematopoietic stem cell Specification and Self-Renewal	$2,286,900
University of California, San Francisco	Thea Tlsty	SEED Grant	Role of the tumor suppressor gene, p16INK4a, in regulating stem cell phenotypes in embryonic stem cells and human epithelial cells.	$639,150
Stanford University	John Hennessy	Major Facilities	No Title	$43,578,000
Scripps Research Institute	Ulrich Mueller	Research Training II	Training Stem Cell Researchers at the Chemistry-Biology Interface	$4,058,362
The J. David Gladstone Institutes	Benoit Bruneau	Basic Biology IV	Epigenetic regulation of human cardiac differentiation	$1,708,560
The Salk Institute for Biological Studies	Ronald Evans	Basic Biology II	Molecular Characterization and Functional Exploration of Nuclear Receptors in hiPSCs	$1,712,880
Sanford-Burnham Medical Research Institute	Marcel Daadi	Disease Team Therapy Planning I	Neural Stem Cell-Based Therapy For Parkinson’s Disease	$99,976
University of California, San Diego	Catriona Jamieson	New Faculty II	Derivation and Characterization of Myeloproliferative Disorder Stem Cells from Human ES Cells	$3,240,572
Stanford University	Phillip Yang	SEED Grant	In Vivo Molecular Magnetic Resonance Imaging of Human Embryonic Stem Cells in Murine Model of Myocardial Infarction	$658,125
University of California, San Diego	Lawrence Goldstein	Disease Team Planning	Human Stem Cell Approaches to Alzheimers Disease Therapies	$55,000
University of California, San Diego	Karl Willert	Shared Labs	Enhancing Facilities for Genetic Manipulation and Engineering of Human Embryonic Stem Cells	$3,711,102
University of California, San Diego	George Sen	Basic Biology IV	Regulation of Epidermal Self-Renewal and Differentiation by Histone and DNA Demethylases.	$1,080,000
Stanford University	Joanna Wysocka	Basic Biology III	Enhancer-mediated gene regulation during early human embryonic development	$1,425,600
BioTime, Inc.	Michael West	Early Translational I	Addressing the Cell Purity and Identity Bottleneck Through Generation and Expansion of Clonal Human Embryonic Progenitor Cell Lines	$4,721,706
University of California, Irvine	Douglas Wallace	Comprehensive Grant	The Dangers of Mitochondrial DNA Heteroplasmy in Stem Cells Created by Therapeutic Cloning	$2,530,000
University of California, Los Angeles	William Lowry	SEED Grant	Modeling Human Embryonic Development with Human Embryonic Stem Cells	$571,575
Sangamo BioSciences, Inc.	Fyodor Urnov	Strategic Partnership II	A Treatment For Beta-thalassemia via High-Efficiency Targeted Genome Editing of Hematopoietic Stem Cells	$6,374,150
University of California, Los Angeles	Zack Jerome	New Cell Lines	Generation of clinical grade human iPS cells	$1,382,400
iPierian, Inc.	John Dimos	Early Translational II	New Drug Discovery for SMA using Patient-derived Induced Pluripotent Stem Cells	$5,665,887
University of California, Berkeley	David Raulet	Transplantation Immunology	Inactivating NK cell reactivity to facilitate transplantation of stem cell derived tissue	$958,808
The J. David Gladstone Institutes	Deepak Srivastava	Comprehensive Grant	microRNA Regulation of Cardiomyocyte Differentiation from Human Embryonic Stem Cells	$3,164,000
University of California, Santa Barbara	Dennis Clegg	Tools and Technologies I	Synthetic Matrices for Stem Cell Growth and Differentiation	$599,998
University of California, Berkeley	Carolyn Bertozzi	SEED Grant	Profiling surface glycans and glycoprotein expression of human embryonic stem cells	$498,409
Children's Hospital of Los Angeles	Tracy Grikscheit	New Faculty Physician Scientist	The generation and expansion of tissue-engineered small intestine from human stem/ progenitor cells: a preclinical study of functional translation	$3,583,000
Beckman Research Institute of City of Hope	John Zaia	Disease Team Research I	ZIinc Finger Nuclease-Based Stem Cell Therapy for AIDS	$14,583,187
Children's Hospital of Oakland Research Institute	Vasanthy Narayanaswami	Creativity Awards	[REDACTED] Summer Stem Cell Research Internship Program for High School Students	$115,500
University of California, San Francisco	Morton Cowan	Early Translational III	Gene Correction of Autologous Hematopoietic Stem Cells in Artemis Deficient SCID	$3,931,662
University of California, Merced	Jennifer Manilay	New Faculty I	Enhancing Survival of Embryonic Stem Cell-Derived Grafts by Induction of Immunological Tolerance	$1,581,056
University of California, Irvine	Michelle Khine	SEED Grant	Micro Platform for Controlled Cardiac Myocyte Differentiation	$363,707
University of California, Los Angeles	Stanley Carmichael	Tools and Technologies II	Development of a Hydrogel Matrix for Stem Cell Growth and Neural Repair after Stroke	$1,825,613
Scripps Research Institute	Kristin Baldwin	Basic Biology III	Identifying sources of mutation in human induced pluripotent stem cells by whole genome sequencing	$1,755,864
Stanford University	Julien Sage	Basic Biology I	The retinoblastoma (RB) gene family in cellular reprogramming	$1,436,185
University of California, Davis	Martin Birchall	Disease Team Therapy Planning I	Airways for Children	$71,218
University of Southern California	Mohammad Pashmforoush	New Faculty I	Transcriptional Regulation of Cardiac Pacemaker Cell Progenitors	$3,149,806
University of California, San Francisco	Valerie Weaver	SEED Grant	Force, Dimensionality and Stem Cell Fate	$561,082
University of California, Berkeley	George Breslauer	Major Facilities	No Title	$20,183,500
University of California, Irvine	Peter Donovan	Research Training II	Research Training Program II	$6,827,148
University of California, San Diego	Miles Wilkinson	Basic Biology IV	Role of the NMD RNA Decay Pathway in Maintaining the Stem-Like State	$1,360,450
iPierian, Inc.	John Dimos	Basic Biology II	Cellular Reprogramming: Dissecting the Molecular Mechanism and Enhancing Efficiency	$1,458,000
University of California, Davis	Jan Nolta	Early Translational I	Sustained siRNA production from human MSC to treat Huntingtons Disease and other neurodegenerative disorders	$2,753,559
University of California, Irvine	Edwin Monuki	New Faculty II	Mechanisms in Choroid Plexus Epithelial Development	$3,169,328
University of California, San Diego	Anirvan Ghosh	SEED Grant	Generation of forebrain neurons from human embryonic stem cells	$612,075
University of California, Los Angeles	Irvin Chen	Disease Team Planning	Stem Cell Therapy for AIDS- Disease Team Planning	$52,500
Buck Institute for Age Research	Xianmin Zeng	Shared Labs	CIRM Shared Research Laboratory for Stem Cells and Aging	$5,883,026
University of California, Los Angeles	Kathrin Plath	Basic Biology IV	Understanding the status of the X chromosomes in human ESCs and preimplantation embryos	$1,382,400
University of California, Los Angeles	Kathrin Plath	Basic Biology III	Discovery of mechanisms that control epigenetic states in human reprogramming and pluripotent cells	$1,364,598
Escape Therapeutics, Inc	Basil Hantash	Transplantation Immunology	Development of an immune tolerant hESC source for allogeneic cell therapy applications	$1,453,040
University of California, Los Angeles	Gay Crooks	Comprehensive Grant	Regulated Expansion of Lympho-hematopoietic Stem and Progenitor Cells from Human Embryonic Stem Cells (hESC)	$2,551,088
Sanford-Burnham Medical Research Institute	Ziwei Huang	SEED Grant	New Chemokine-Derived Therapeutics Targeting Stem Cell Migration	$759,000
Calimmune, Inc.	Geoff Symonds	Disease Team Research I	GENE-MODIFIED HEMATOPOIETIC STEM/PROGENITOR CELL BASED THERAPY FOR HIV DISEASE	$8,278,722
Sanford-Burnham Medical Research Institute	Zhuohua Zhang	New Cell Lines	Derivation of Parkinson's Disease Coded-Stem Cells (PD-SCs)	$1,589,760

Humboldt State University	Jacob Varkey	Bridges	CIRM Bridges to Stem Cell Research Certificate Program	$3,497,510
University of California, Davis	Roslyn Isseroff	Early Translational II	Bone Marrow Mesenchymal Stem Cells to Heal Chronic Diabetic Wounds	$4,640,338
Stanford University	Kenneth Weinberg	Transplantation Immunology	“Engineered immune tolerance by Stem Cell-derived thymic regeneration”	$1,415,836
University of California, Los Angeles	Guoping Fan	Comprehensive Grant	Epigenetic gene regulation during the differentiation of human embryonic stem cells: Impact on neural repair	$2,516,613
University of California, San Diego	Ying Liu	Tools and Technologies I	Generation of disease models for neurodegenerative disorders in hESCs by gene targeting	$869,262
Stanford University	Krishna Shenoy	SEED Grant	Technology for hESC-Derived Cardiomyocyte Differentiation and Optimization of Graft-Host Integration in Adult Myocardium	$634,287
University of California, San Francisco	Ophir Klein	New Faculty Physician Scientist	Stem cell therapy for inflammatory bowel disease	$3,259,000
University of California, Los Angeles	Irvin Chen	Disease Team Research I	HPSC based therapy for HIV disease using RNAi to CCR5.	$9,905,604
Stanford University	Joseph Wu	Disease Team Therapy Development - Research	Human Embryonic Stem Cell-Derived Cardiomyocytes for Patients with End Stage Heart Failure	$19,999,899
University of California, San Diego	Eric Adler	Early Translational III	Identification of Novel Therapeutics for Danon Disease Using an iPS Model of the Disease	$1,701,575
Stanford University	Joanna Wysocka	New Faculty I	Trithorax and Polycomb methyltransferase complexes in cell fate determination.	$2,374,020
University of California, Riverside	Frank Sauer	SEED Grant	Non-coding RNA as tool for the active control of stem cell differentiation	$595,469
University of California, San Francisco	Daniel Lim	Tools and Technologies II	Development and preclinical testing of new devices for cell transplantation to the brain.	$1,831,723
University of California, San Francisco	John Murnane	Basic Biology III	Genomic instability during culturing of human embryonic stem cells	$1,074,355
Stanford University	Helen Blau	Basic Biology I	Molecular Mechanisms of Reprogramming towards Pluripotency	$1,414,841
University of California, Los Angeles	Antoni Ribas	Disease Team Therapy Planning I	Genetic Re-programming of Stem Cells to Fight Cancer	$110,000
University of California, Irvine	Andrew Putnam	New Faculty I	A Novel Engineered Niche to Explore the Vasculogenic Potential of Embryonic Stem Cells	$2,108,683
Sanford-Burnham Medical Research Institute	Alexey Terskikh	SEED Grant	Analysis of Candidate Neural Crest Cells Derived from Human ES Cells	$759,000
University of California, Davis	Larry Vanderhoef	Major Facilities	No Title	$20,082,400
University of California, San Francisco	Susan Fisher	Research Training II	Training Program in Stem Cell Research	$7,946,605
Stanford University	Ben Barres	Basic Biology IV	Phenotyping Human Astrocytes in Health and Disease	$1,385,517
University of California, Davis	Eric Kurzrock	Basic Biology II	Differentiation of Human Embryonic Stem Cells into Urothelium	$1,328,400
University of California, Irvine	Frank LaFerla	Early Translational I	Neural Stem Cells as a Developmental Candidate to Treat Alzheimer Disease	$3,599,997
University of Southern California	Gage DeKoeyer Crump	New Faculty II	Skeletogenic Neural Crest Cells in Embryonic Development and Adult Regeneration of the Jaw	$2,396,871
University of California, Irvine	Brian Cummings	SEED Grant	The Immunological Niche: Effect of immunosuppressant drugs on stem cell proliferation, gene expression, and differentiation in a model of spinal cord injury.	$619,223
Buck Institute for Age Research	Xianmin Zeng	Disease Team Planning	Develop a cell replacement therapy for Parkinson's disease using human embryonic stem cells	$55,000
The J. David Gladstone Institutes	Deepak Srivastava	Shared Labs	CIRM Shared Human Embryonic Stem Cell Core Laboratory	$2,621,345
The J. David Gladstone Institutes	Sheng Ding	Basic Biology IV	A new paradigm of lineage-specific reprogramming	$1,708,560
University of California, San Francisco	Jason Pomerantz	Basic Biology III	Phenotypic Analysis of Human ES Cell-Derived Muscle Stem Cells	$1,381,296
Palo Alto Institute for Research and Education, Inc.	Husein Hadeiba	Transplantation Immunology	Application of Tolerogenic Dendritic Cells for Hematopoietic Stem Cell Transplantation	$885,475
University of California, Davis	Mark Zern	Comprehensive Grant	An in vitro and in vivo comparison among three different human hepatic stem cell populations	$2,504,614
University of California, San Diego	Catriona Jamieson	SEED Grant	Derivation and Characterization of Cancer Stem Cells from Human ES Cells	$642,500
University of California, Los Angeles	Irvin Chen	Early Translational from Disease Team Conversion	HPSC based therapy for HIV disease using RNAi to CCR5.	$1,505,000
Stanford University	Julie Baker	New Cell Lines	Derivation of hESC Lines with Disease Lesions	$1,424,412
Pasadena City College	Pamela Eversole-Cire	Bridges	Bridges to Stem Cell Research	$3,609,138
University of California, San Francisco	Markus Muschen	Early Translational II	Dual targeting of tyrosine kinase and BCL6 signaling for leukemia stem cell eradication	$3,607,305
Scripps Research Institute	Nicholas Gascoigne	Transplantation Immunology	Role of Innate Immunity in hematopoeitic stem cell-mediated allograft tolerance	$1,746,684
University of California, San Francisco	Susan Fisher	Comprehensive Grant	Constructing a fate map of the human embryo	$2,532,388
ViaCyte, Inc.	Evert Kroon	Tools and Technologies I	Development of the Theracyte Cellular Encapsulation System for Delivery of human ES Cell-derived Pancreatic Islets and Progenitors.	$827,072
Stanford University	Calvin Kuo	SEED Grant	Differentiation of Human Embryonic Stem Cells to Intestinal Fates	$578,943
University of California, San Francisco	Jason Pomerantz	New Faculty Physician Scientist	Characterization of Human Skeletal Muscle Stem Cells for Clinical Application	$3,259,000
University of California, San Francisco	Mitchel Berger	Disease Team Research I	Stem Cell-Mediated Oncocidal Gene Therapy of Glioblastoma (GBM)	$19,162,435
University of California, Davis	Gerhard Bauer	Creativity Awards	Internship at a Cutting Edge CIRM-funded Stem Cell Research Facility	$264,000
University of California, San Francisco	Holger Willenbring	Early Translational III	Generation of safe and therapeutically effective human induced hepatocyte-like cells	$1,544,170
Scripps Research Institute	Kristin Baldwin	New Faculty I	Generating pluripotent cell lines from neurons.	$2,803,375
University of California, San Francisco	Holger Willenbring	SEED Grant	Induction of pluripotency in fibroblasts by fusion with enucleated human embryonic stem cell syncytia	$342,962
Fluidigm Corporation	Marc Unger	Tools and Technologies II	Development and Application of Versatile, Automated, Microfluidic Cell Culture System	$1,943,904
University of California, Berkeley	Michael Rape	Basic Biology III	Ubiquitin-dependent control of hESC self-renewal and expansion	$1,364,091
Palo Alto Institute for Research and Education, Inc.	Tony Wyss-Coray	Basic Biology II	Systemic Protein Factors as Modulators of the Aging Neurogenic Niche	$1,522,800
Stanford University	Albert Wong	Disease Team Therapy Planning I	Recombinant Bispecific Antibody Targeting Cancer Stem Cells for the Therapy of Glioblastoma	$109,750
Western University of Health Sciences	Douglas Ethell	New Faculty I	ES-Derived Cells for the Treatment of Alzheimer's Disease	$2,120,833
The Salk Institute for Biological Studies	Beverly Emerson	SEED Grant	Regulation of Specific Chromosomal Boundary Elements by CTCF Protein Complexes in Human Embryonic Stem Cells	$678,788
University of California, Irvine	Michael Drake	Major Facilities	No Title	$27,156,000
University of California, San Diego	Sylvia Evans	Research Training II	Interdisciplinary Stem Cell Training Program	$7,890,588
Stanford University	Gerald Crabtree	Basic Biology IV	Mechanism and Utility of Direct Neuronal Conversion with a MicroRNA-Chromatin Switch	$1,392,426
University of California, San Diego	Charles King	Basic Biology III	Biological relevance of microRNAs in hESC differentiation to endocrine pancreas	$1,313,649
University of California, San Diego	Yang Xu	Early Translational I	Developing induced pluripotent stem cells into human therapeutics and disease models	$5,165,028
University of California, San Francisco	Jeremy Reiter	New Faculty II	High throughput modeling of human neurodegenerative diseases in embryonic stem cells	$2,259,092
Sanford-Burnham Medical Research Institute	Hudson Freeze	SEED Grant	Role of Glycans in Human Embryonic Stem Cell Conversion to Neural Precursor Cells	$759,000
University of California, Irvine	Henry Klassen	Disease Team Planning	Stem cells for neuroprotection of photoreceptors in retinitis pigmentosa	$37,367
University of California, Santa Cruz	Lindsay Hinck	Shared Labs	Shared Stem Cell Facility	$3,588,740
University of California, Los Angeles	Owen Witte	Basic Biology IV	Trop2 dependent and independent mechanisms of self-renewal in human cancer stem cells	$1,382,400
University of California, San Francisco	Arturo Alvarez-Buylla	Early Translational II	Inhibitory Nerve Cell Precursors: Dosing, Safety and Efficacy	$1,752,058
University of California, Los Angeles	Gay Crooks	Transplantation Immunology	Engineering Thymic Regeneration to Induce Tolerance	$1,357,398
Stanford University	Stefan Heller	Comprehensive Grant	Generation of inner ear sensory cells from human ES cells toward a cure for deafness	$2,469,373
Stanford University	Mark Kay	SEED Grant	Novel vectors for gene transfer into human ES cells	$640,642
University of California, Los Angeles	Stanley Nelson	Early Translational from Disease Team Conversion	Combination therapy to Enhance Antisense Mediated Exon Skipping for Duchenne Muscular Dystrophy	$6,000,000
Stanford University	Michele Calos	New Cell Lines	Safe, efficient creation of human induced pluripotent stem cells without the use of retroviruses	$1,406,875
San Diego State University	Ralph Feuer	Bridges	CIRM Stem Cell Internship Program	$3,597,177
University of California, Los Angeles	Bruno Peault	Early Translational II	Harnessing native fat-residing stem cells for bone regeneration	$5,391,560
University of California, Berkeley	Ellen Robey	Transplantation Immunology	Human Immune System Mouse models as preclinical platforms for stem cell derived grafts	$1,079,393
Stanford University	Judith Shizuru	Disease Team Therapy Development - Research	A monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants	$20,000,000
The Salk Institute for Biological Studies	Fred Gage	Comprehensive Grant	Molecular and Cellular Transitions from ES Cells to Mature Functioning Human Neurons	$2,879,210
Fluidigm Corporation	Marc Unger	Tools and Technologies I	Scaleup of Versatile, Fully Automated, Microfluidic Cell Culture System	$749,520
University of California, Los Angeles	Irvin Chen	SEED Grant	Genetic modification of the human genome to resist HIV-1 infection and/or disease progression	$642,652
University of California, San Francisco	Ann Zovein	New Faculty Physician Scientist	Human endothelial reprogramming for hematopoietic stem cell therapy.	$3,259,000
University of Southern California	Mark Humayun	Disease Team Research I	Stem cell based treatment strategy for Age-related Macular Degeneration (AMD)	$18,904,916
The J. David Gladstone Institutes	Shannon Noonan	Creativity Awards	[REDACTED] Summer Scholars internship program	$30,690
The J. David Gladstone Institutes	Deepak Srivastava	Early Translational III	Direct Cardiac Reprogramming for Heart Regeneration	$6,319,110
University of California, Los Angeles	Dana Jones	New Faculty I	Characterization of mechanisms regulating de-differentiation and the re-acquisition of stem cell identity	$2,675,234
University of California, San Francisco	Didier Stainier	SEED Grant	Endodermal differentiation of human ES cells	$635,242
Stanford University	Michele Calos	Tools and Technologies II	Site-specific integration of Lmx1a, FoxA2, & Otx2 to optimize dopaminergic differentiation	$1,619,627
Beckman Research Institute of City of Hope	Stephen Forman	Early Translational III	Targeting glioma cancer stem cells with receptor-engineered self-renewing memory T cells	$5,217,004
University of California, Los Angeles	Douglas Black	Basic Biology II	Programs of alternative splicing regulation by polypyrimidine tract binding protein	$1,350,994
Sanford-Burnham Medical Research Institute	Stuart Lipton	Disease Team Therapy Planning I	hESC-derived NPCs Programmed with MEF2C for Cell Transplantation in Parkinson’s Disease	$96,448
The J. David Gladstone Institutes	Sheng Ding	New Faculty I	Reprogramming of human somatic cells back to pluripotent embryonic stem cells	$2,943,375
Stanford University	Aaron Hsueh	SEED Grant	Patient-specific cells with nuclear transfer	$656,074
University of California, Los Angeles	Gene Block	Major Facilities	No Title	$19,854,900
University of California, Santa Cruz	David Haussler	Research Training II	CIRM Training Program in Systems Biology of Stem cells	$4,591,616
University of California, San Diego	Ananda Goldrath	Basic Biology IV	Mechanisms to protect hESC-derived cells from allogenic immune rejection	$1,161,000
University of California, San Diego	Kun Zhang	Basic Biology III	Functional characterization of mutational load in nuclear reprogramming and differentiation	$1,382,140
Scripps Research Institute	Jeanne Loring	Early Translational I	Ensuring the safety of cell therapy: a quality control pipeline for cell purification and validation	$6,292,290
University of California, Merced	Kara McCloskey	New Faculty II	Building Cardiac Tissue from Stem Cells and Natural Matrices	$1,706,255
University of Southern California	Qilong Ying	SEED Grant	Self-renewal of human embryonic stem cells	$663,209
Ludwig Institute for Cancer Research	Webster Cavenee	Disease Team Planning	Stem Cell-Mediated Oncocidal Therapy of Primary & Metastatic Brain Tumors	$55,000
University of California, Los Angeles	Owen Witte	Shared Labs	CIRM Shared Research Laboratories	$3,740,497
University of California, San Diego	David Traver	Basic Biology IV	DECIPHERING THE INSTRUCTIONS FOR VERTEBRATE HSC SPECIFICATION AND AMPLIFICATION.	$1,363,698
University of California, Irvine	Brian Cummings	Early Translational II	Neural restricted, FAC-sorted, human neural stem cells to treat traumatic brain injury	$1,708,549
University of California, San Diego	Yang Xu	Transplantation Immunology	Induction of immune tolerance to human embryonic stem cell-derived allografts	$1,193,292
University of California, San Francisco	Randall Lee	Comprehensive Grant	Embryonic Stem Cell-Derived Therapies Targeting Cardiac Ischemic Disease	$2,524

Stanford University	Julien Sage	SEED Grant	Functions of RB family proteins in human embryonic stem cells	$520,777
University of California, Los Angeles	Amander Clark	New Cell Lines	Generation of Pluripotent Cell Lines from Human Embryos	$1,177,648
San Francisco State University	Carmen Domingo	Bridges	Bridges to Stem Cell Research	$3,594,705
Cedars-Sinai Medical Center	Dan Gazit	Early Translational II	Systemic Adult Stem Cell Therapy for Osteoporosis-Related Vertebral Compression Fractures	$1,927,698
University of California, Los Angeles	Antoni Ribas	Disease Team Therapy Development - Research	Genetic Re-programming of Stem Cells to Fight Cancer	$19,999,563
University of California, San Diego	Lawrence Goldstein	Comprehensive Grant	Using Human Embryonic Stem Cells to Understand and to Develop New Therapies for Alzheimer's Disease	$2,512,664
University of California, Merced	Michael Cleary	Tools and Technologies I	RNA Analysis by Biosynthetic Tagging (RABT): a tool for the identification of cell type-specific RNAs	$483,803
University of California, San Francisco	Robert Blelloch	SEED Grant	MicroRNA Regulation of Human Embryonic Stem Cell Self-Renewal and Differentiation	$631,831
University of California, Los Angeles	Reza Ardehali	New Faculty Physician Scientist	Preclinical evaluation of human embryonic stem cell-derived cardiovascular progenitors	$3,105,388
University of California, San Diego	Lawrence Goldstein	Disease Team Research I	Stem Cell-Derived Astrocyte Precursor Transplants in Amyotrophic Lateral Sclerosis	$10,857,762
University of Southern California	Roberta Brinton	Creativity Awards	CIRM STAR High School Summer Research and Creativity Program	$264,000
Stanford University	Helen Blau	Early Translational III	Local Delivery of Rejuvenated Old Muscle Stem Cells to Increase Strength in Aged Patients	$1,825,920
University of California, Berkeley	Irina Conboy	New Faculty I	Identification of hESC-mediated molecular mechanism that positively regulates the regenerative capacity of post-natal tissues	$2,246,020
University of California, Davis	Ebenezer Yamoah	SEED Grant	Hair Cells and Spiral Ganglion Neuron Differentiation from Human Embryonic Stem Cells	$469,327
University of California, San Diego	Shu Chien	Tools and Technologies II	Development of Synthetic Microenvironments for Stem Cell Growth and Differentiation	$1,832,515
Stanford University	Joseph Wu	Early Translational III	Heart Repair with Human Tissue Engineered Myocardium	$4,766,231
University of California, Los Angeles	Yong Kim	Basic Biology II	Novel Mechanism in Self-Renewal/Differentiation of Human Embryonic Stem Cells	$1,259,371
Geron Corporation	Jane Lebkowski	Disease Team Therapy Planning I	Preclinical Development and First-In-Human Testing of [REDACTED] in Advanced Heart Failure	$106,239
University of California, Los Angeles	Antoni Ribas	New Faculty II	Stem Cells for Immune System Regeneration to Fight Cancer	$3,247,000
University of Southern California	Peter Laird	SEED Grant	Screening for Oncogenic Epigenetic Alterations in Human ES Cells	$685,000
University of California, Merced	John White	Major Facilities	No Title	$4,359,480
The Salk Institute for Biological Studies	Juan Carlos Izpisua Belmonte	Research Training II	Training in the Biology of Human Embryonic Stem Cells and Emerging Technologies II	$3,062,677
Stanford University	Roel Nusse	Basic Biology IV	Asymmetric stem cell division oriented by a local self-renewing signal	$1,195,811
University of California, San Diego	Farah Sheikh	Basic Biology III	Molecular Mechanisms Underlying Human Cardiac Cell Junction Maturation and Disease Using Human iPSC	$1,341,955
ViaCyte, Inc.	Olivia Kelly	Early Translational I	Methods for detection and elimination of residual human embryonic stem cells in a differentiated cell product	$5,405,397
University of California, Davis	Paul Knoepfler	New Faculty II	Molecular mechanisms governing hESC and iPS cell self-renewal and pluripotency	$2,158,161
Stanford University	Susan McConnell	SEED Grant	Optimization of guidance response in human embryonic stem cell derived midbrain dopaminergic neurons in development and disease	$633,170
Children's Hospital of Oakland Research Institute	Mark Walters	Disease Team Planning	CIRM Disease Team Planning Award	$55,000
The Salk Institute for Biological Studies	Inder Verma	Shared Labs	Shared viral vector facility for genetic manipulation of human ES cell	$4,316,515
Stanford University	Michelle Monje	Basic Biology IV	Stem Cell Mechanisms Governing Discrete Waves of Gliogenesis in the Childhood Brain	$1,264,248
Beckman Research Institute of City of Hope	Yanhong Shi	Early Translational II	Developing a therapeutic candidate for Canavan disease using induced pluripotent stem cell	$1,835,983
University of California, San Francisco	Mark Anderson	Transplantation Immunology	Stem cell differentiation to thymic epithelium for inducing tolerance to stem cells	$1,314,090
Stanford University	Roel Nusse	Comprehensive Grant	Guiding the developmental program of human embryonic stem cells by isolated Wnt factors	$2,354,820
Scripps Research Institute	Peter Schultz	SEED Grant	A Chemical Approach to Stem Cell Biology	$784,900
The J. David Gladstone Institutes	Bruce Conklin	New Cell Lines	Induced Pluripotent Stem Cells for Cardiovascular Diagnostics	$1,708,560
San Jose State University	Tzvia Abramson	Bridges	Stem Cell Internships for Laboratory-based Learning (SCILL)	$3,614,907
Stanford University	Michele Calos	Early Translational II	Stem Cell Therapy for Duchenne Muscular Dystrophy	$2,325,933
University of California, Irvine	leif Havton	Early Translational II	Repair of Conus Medullaris/Cauda Equina Injury using Human ES Cell-Derived Motor Neurons	$1,614,441
University of California, Davis	Nancy Lane	Disease Team Therapy Development - Research	Treatment of osteoporosis with endogenous Mesenchymal stem cells	$19,999,867
University of California, San Diego	Martin Marsala	Comprehensive Grant	Spinal ischemic paraplegia: modulation by human embryonic stem cell implant	$2,445,716
University of California, Santa Cruz	Joel Kubby	Tools and Technologies I	AO Wide-Field Microscope	$552,985
Buck Institute for Age Research	Dale Bredesen	SEED Grant	Programmed Cell Death Pathways Activated in Embryonic Stem Cells	$734,202
ViaCyte, Inc.	Howard Foyt	Strategic Partnership I	Preclinical and clinical testing of a stem cell-based combination product for insulin-dependent diabetes	$10,075,070
Beckman Research Institute of City of Hope	Paul Salvaterra	Creativity Awards	Creativity Award Program in Stem Cell Biology for California High School Students	$211,200
University of California, San Diego	Mark Tuszynski	Early Translational III	Functional Neural Relay Formation by Human Neural Stem Cell Grafting in Spinal Cord Injury	$4,699,569
University of California, Santa Cruz	Bin Chen	New Faculty I	Molecular mechanisms of neural stem cell differentiation in the developing brain	$2,200,715
University of California, Irvine	Kyoko Yokomori	SEED Grant	Derivation and characterization of human ES cells from FSHD embryos	$632,500
University of California, Berkeley	Steven Conolly	Tools and Technologies II	Magnetic Particle Imaging: A Novel Ultra-sensitive Imaging Scanner for Tracking Stem Cells In Vivo	$1,452,360
University of California, Irvine	Thomas Lane	Early Translational III	Multiple Sclerosis therapy: Human Pluripotent Stem Cell-Derived Neural Progenitor Cells	$4,799,814
Stanford University	Steven Artandi	Basic Biology II	Self-renewal and senescence in iPS cells derived from patients with a stem cell disease	$1,430,908
University of Southern California	Roberta Brinton	Disease Team Therapy Planning I	A CIRM Disease Team to Develop Allopregnanolone for Prevention and Treatment of Alzheimer's Disease	$107,989
The J. David Gladstone Institutes	Benoit Bruneau	New Faculty II	Induction of cardiogenesis in pluripotent cells via chromatin remodeling factors	$2,847,600
University of California, Irvine	Thomas Lane	SEED Grant	Human Embryonic Stem Cells and Remyelination in a Viral Model of Demyelination	$425,594
University of California, Santa Barbara	Glenn Lucas	Major Facilities	No Title	$3,205,800
University of California, Santa Barbara	Dennis Clegg	Research Training II	Training Program in Stem Cell Biology and Engineering	$2,451,273
University of California, San Diego	Eugene Yeo	Basic Biology IV	Stem cell models to analyze the role of mutated C9ORF72 in neurodegeneration	$1,393,200
University of California, San Diego	David Cheresh	Basic Biology III	Molecular basis of human ES cell neurovascular differentiation and co-patterning	$1,361,448
Scripps Health	Darryl D'Lima	Early Translational I	Stem Cell-Based Therapy for Cartilage Regeneration and Osteoarthritis	$3,118,431
University of California, Berkeley	Lin He	New Faculty II	The roles of non-coding RNAs in the self-renewal and differentiation of pluripotent stem cells	$1,499,994
University of California, Irvine	Charles Limoli	SEED Grant	Using human embryonic stem cells to treat radiation-induced stem cell loss: Benefits vs cancer risk	$625,617
Cedars-Sinai Medical Center	Eduardo Marbán	Disease Team Planning	{REDACTED} Heart Disease Regenerative Medicine Team Planning Award	$46,886
University of California, Irvine	Peter Donovan	Shared Labs	Regional Human Embryonic Stem Cell Shared Research Laboratory and Stem Cell Techniques Course	$5,572,979
Cedars-Sinai Medical Center	Eduardo Marbán	Basic Biology IV	Mechanism of heart regeneration by cardiosphere-derived cells	$1,367,604
Buck Institute for Age Research	Xianmin Zeng	Early Translational II	Banking transplant ready dopaminergic neurons using a scalable process	$6,016,624
La Jolla Institute for Allergy and Immunology	Anjana Rao	Transplantation Immunology	Generation of regulatory T cells by reprogramming	$1,503,998
University of California, Davis	Alice Tarantal	Comprehensive Grant	Preclinical Model for Labeling, Transplant, and In Vivo Imaging of Differentiated Human Embryonic Stem Cells	$2,257,040
University of California, Irvine	Vincent Procaccio	SEED Grant	Mitochondrial Dysfunction in Embryonic Stem Cells	$632,500
University of California, San Diego	Steve Dowdy	New Cell Lines	Protein transduction of transcription factors: a non-genetic approach to generate new pluripotent cell lines from human skin.	$1,387,800
The Salk Institute for Biological Studies	Fred Gage	Early Translational II	Crosstalk: Inflammation in Parkinson’s disease (PD) in a humanized in vitro model	$2,472,839
University of California, Davis	John Laird	Disease Team Therapy Development - Research	Phase I study of IM Injection of VEGF-Producing MSC for the Treatment of Critical Limb Ischemia	$14,184,595
Sanford-Burnham Medical Research Institute	Mark Mercola	Comprehensive Grant	Chemical Genetic Approach to Production of hESC-derived Cardiomyocytes	$3,036,002
University of California, Irvine	Orhan NALCIOGLU	Tools and Technologies I	A Multimodality Molecular Imaging Systen (MRSPECT) for in Vivo Stem Cell Tracking	$719,798
Human BioMolecular Research Institute	John Cashman	SEED Grant	Discovering Potent Molecules with Human ESCs to Treat Heart Disease	$714,654
Bluebird Bio	David Davidson	Strategic Partnership I	A Phase 1/2, Open Label Study Evaluating the Safety and Efficacy of Gene Therapy in Subjects with β-Thalassemia by Transplantation of Autologous Hematopoietic Stem Cells [REDACTED]	$9,363,335
Gamma Medica-Ideas, Inc.	James Hugg	Tools and Technologies II	Tri-resolution Visualization System for Stem Cells and Tissue Regeneration Monitoring	$1,528,599
Scripps Research Institute	James Williamson	Creativity Awards	Stem Cell Summer Academy: Creating the Next Generation of Scientists	$206,250
University of California, San Diego	Karl Willert	Basic Biology I	WNT signaling and the control of cell fate decisions in human pluripotent stem cells.	$1,376,802
Stanford University	Renee Reijo Pera	Early Translational III	Autologous iPSC Therapy for Urinary Incontinence	$5,279,607
Stanford University	Karl Deisseroth	New Faculty I	Bioengineering technology for fast optical control of differentiation and function in stem cells and stem cell progeny	$3,154,719
University of California, Los Angeles	Siavash Kurdistani	SEED Grant	Cellular epigenetic diversity as a blueprint for defining the identity and functional potential of human embryonic stem cells	$641,047
University of California, San Diego	Lawrence Goldstein	Tools and Technologies II	Developing a method for rapid identification of high-quality disease specific hIPSC lines	$1,816,157
University of California, Davis	Walter Boyd	Early Translational III	Extracellular Matrix Bioscaffold Augmented with Human Stem Cells for Cardiovascular Repair	$4,939,140
Sanford-Burnham Medical Research Institute	Huei-sheng Chen	Basic Biology II	Endothelial cells and ion channel maturation of human stem cell-derived cardiomyocytes	$1,823,362
Samumed, LLC	John Hood	Disease Team Therapy Planning I	Clinical Development of an osteoinductive therapy to prevent osteoporosis-related fractures	$99,110
University of California, Los Angeles	Brigitte Gomperts	New Faculty II	Stem Cells in Lung Cancer	$2,556,572
University of California, San Diego	Cornelis Murre	SEED Grant	Generation of long-term cultures of human hematopoietic multipotent progenitors from embryonic stem cells	$538,211
University of California, Santa Cruz	Margaret Delaney	Major Facilities	No Title	$7,191,950
Stanford University	Renee Reijo Pera	Research Training II	CIRM Training Program	$7,974,291
University of California, San Francisco	Barbara Panning	Basic Biology IV	Investigation of the role of O-GlcNAcylation in SOX2 function during reprogramming	$1,285,214
University of California, San Diego	Binhai Zheng	Basic Biology III	Generation and characterization of corticospinal neurons from human embryonic stem cells	$1,355,063
Scripps Research Institute	Martin Friedlander	Early Translational I	Autologous Retinal Pigmented Epithelial Cells Derived from Induced Pluripotent Stem Cells for the Treatment of Atrophic Age Related Macular Degeneration	$5,945,738
University of California, San Diego	Mana Parast	New Faculty II	Molecular Mechanisms of Trophoblast Stem Cell Specification and Self-Renewal	$3,253,580
University of California, Irvine	Frank LaFerla	SEED Grant	Development of human ES cell lines as a model system for Alzheimer disease drug discovery	$492,750
University of California, Irvine	Leslie Thompson	Disease Team Planning	Huntington's Disease Team	$54,618
Children's Hospital of Los Angeles	David Warburton	Shared Labs	hESC Facility	$3,756,666
California Polytechnic State University, San Luis Obispo	Trevor Cardinal	Bridges	Masters of Science Specialization in Stem Cell Technology	$3,020,182
University of California, Davis	Mark Zern	Early Translational II	Liver Cell Transplantation	$5,199,767
University of California, Davis	William Murphy	Transplantation Immunology	Donor natural killer (NK) cells as “veto” cells to promote donor-specific tolerance	$1,317,569
University of California, San Diego	Yang Xu	Comprehensive Grant	Mechanisms to maintain the self-renewal and genetic stability of human embryonic stem cells	$2,570,000
University of California, Davis	A. Reddi	SEED Grant	hESCs for Articular Cartilage Regeneration	$367,650 University of California, San Francisco Susan Fisher New Cell Lines Optimization of Human Embryonic Stem Cell Derivation Techniques and Production/Distribution of GMP-Grade Lines $1,383,419 The Parkinson's Institute Dennis Steindler Research Leadership 10 Stem Cell Pathologies in Parkinson’s disease as a key to Regenerative Strategies $6,718,471 University of Southern California Andrew McMahon Research Leadership 10 Repair and regeneration of the nephron $5,672,206 University of California, San Diego Dennis Carson Disease Team Research I Development of Highly Active Anti-Leukemia Stem Cell Therapy (HALT) $19,999,826 University of California, Davis Vicki Wheelock Disease Team Therapy Development - Research MSC engineered to produce BDNF for the treatment of Huntington's disease $18,950,061 Scripps Research Institute Peter Schultz Training Grant I-2 Training Grant I $1,059,300 University of California, Los Angeles Michael Phelps Tools and Technologies I Novel Tools and Technologies for Translational PET Imaging of Cell-based Therapies $914,096 University of California, Irvine Grant MacGregor SEED Grant Production of Oocytes from Human ES Cells $623,781 University of California, Davis Emanual Maverakis New Faculty Physician Scientist Tunable hydrogels for therapeutic delivery of multipotent stem cells. $3,139,000 Stanford University Brian Rutt Tools and Technologies II Development of Single Cell MRI Technology using Genetically-Encoded Iron-Based Reporters $1,930,608 University of California, San Francisco Katherine Nielsen Creativity Awards [REDACTED] SEP High School Intern Program $143,550 University of California, Los Angeles Robb Maclellan Basic Biology I Human Cardiovascular Progenitors, their Niches and Control of Self-renewal and Cell Fate $1,378,076 University of California, San Diego Yang Xu Early Translational III Human ES cell based therapy of heart failure without allogenic immune rejection $1,857,600 University of California, Los Angeles Kathrin Plath New Faculty I In vitro reprogramming of mouse and human somatic cells to an embryonic state $2,229,427 The J. David Gladstone Institutes Fen-Biao Gao SEED Grant MicroRNAs in Human Stem Cell Differentiation and Mental Disorders $791,000 University of Southern California Martin Pera New Cell Lines New Technology ForThe Derivation of Human Pluripotent Stem Cell Lines For Clinical Use $1,387,508 GMR Epigenetics Jifan Hu Tools and Technologies II Robust generation of induced pluripotent stem cells by a potent set of engineered factors $1,452,693 University of Southern California Toshio Miki Early Translational III Generation of hepatic cell from placental stem cell for congenital metabolic disorders $1,750,375 University of California, San Francisco John Rubenstein Basic Biology II MGE Enhancers to Select for Interneuron Precursors Produced from Human ES Cells $1,387,800 OncoMed Pharmaceuticals, Inc. Timothy Hoey Disease Team Therapy Planning I [REDACTED]: A New Cancer Therapeutic to Reduce CSC Frequency $65,120 Ludwig Institute for Cancer Research Bing Ren New Faculty II Mechanisms of chromatin dynamics at enhancers during ES cell differentiation $1,726,564 Sanford-Burnham Medical Research Institute Robert Oshima SEED Grant Trophoblast differentiation of human ES cells. $748,240 University of California, San Francisco Jeffrey Bluestone Disease Team Planning A CIRM Disease Team for the Treatment and Cure of Diabetes $55,000 Buck Institute for Age Research David Greenberg Research Training II CIRM Research Training Program in Stem Cells and Aging $3,178,692 University of California, Berkeley Robert Tjian Basic Biology IV Transcriptional regulation of pluripotency in human embryonic stem cells $1,220,968 University of California, Los Angeles Yi Sun Basic Biology III Studying neurotransmission of normal and diseased human ES cell-derived neurons in vivo $1,382,400 The J. David Gladstone Institutes Warner Greene Early Translational I Maximizing the Safety of Induced Pluripotent Stem Cells as an Infusion Therapy: Limiting the Mutagenic Threat of Retroelement Retrotransposition during iPSC Generation, Expansion and Differentiation $1,327,973 University of California, San Francisco Ophir Klein New Faculty II Laying the groundwork for building a tooth: analysis of dental epithelial stem cells $3,250,251 University of California, San Francisco Linda Giudice SEED Grant Human Embryonic Stem Cell Differentiation to Trophoblast: Basic Biology and Clinical Translation to Improve Human Fertility $640,399 Children's Hospital of Los Angeles Donald Kohn Disease Team Planning STEM CELL GENE THERAPY FOR SICKLE CELL DISEASE $33,110 University of Southern California Andrew McMahon Shared Labs Center for Stem Cell and Regenerative Medicine: Shared Research Laboratory and Course in Current Protocols in Human Embryonic Stem Cell Research $5,355,969 California State Polytechnic University, Pomona Jill Adler-Moore Bridges Collaborative CIRM Bridges Program to Enhance Stem Cell Research Training and Education $3,008,975 University of California, Los Angeles Noriyuki Kasahara Early Translational II Stem cell-based carriers for RCR vector delivery to glioblastoma $3,370,607 Stanford University Christopher Contag Transplantation Immunology Engineering Embryonic Stem Cell Allografts for Operational Tolerance $1,447,956 Stanford University Julie Baker Comprehensive Grant Functional Genomic Analysis of Chemically Defined Human Embryonic Stem Cell $2,628,635 University of Southern California Pin Wang Tools and Technologies I Development of Baculoviral Vectors for Gene Editing of Human Stem Cells $951,104 The J. David Gladstone Institutes Robert Farese New Cell Lines Establishment of Frontotemporal Dementia Patient-Specific Induced Pluripotent Stem (iPS) Cell Lines with Defined Genetic Mutations $1,708,560 The Salk Institute for Biological Studies Fred Gage New Cell Lines Development of Induced Pluripotent Stem Cells for Modeling Human Disease $1,737,720 Stanford University Michael Longaker Training Grant I-1 Stanford CIRM Training Program $3,733,707 Stanford University Alfred Lane Disease Team Research I iPS Cell-Based Treatment of Dominant Dystrophic Epidermolysis Bullosa $11,709,574 Cedars-Sinai Medical Center Clive Svendsen Disease Team Therapy Development - Research Progenitor Cells Secreting GDNF for the Treatment of ALS $17,842,617 The J. David Gladstone Institutes Robert Mahley Training Grant I-2 Gladstone CIRM Scholar Program $2,397,240 Vala Sciences, Inc. Patrick McDonough Tools and Technologies I Optimization in the Identification, Selection and Induction of Maturation of Subtypes of Cardiomyocytes derived from Human Embryonic Stem Cells $906,629 University of California, Riverside Michael Pirrung SEED Grant Stem Cell Survival and Differentiation Through Chemical Genetics $543,987 University of California, Los Angeles Ali Nsair New Faculty Physician Scientist Human Induced Pluripotent Stem Cell-Derived Cardiovascular Progenitor Cells for Cardiac Cell Therapy. $3,179,315 Stanford University Irving Weissman Tools and Technologies II Antibody tools to deplete or isolate teratogenic, cardiac, and blood stem cells from hESCs $1,869,487 University of California, Los Angeles Gay Crooks Basic Biology III Forming the Hematopoietic Niche from Human Pluripotent Stem Cells $1,375,983 University of California, Davis Min Zhao Basic Biology I Directing migration of human stem cells with electric fields $1,052,715 University of California, San Diego Eugene Yeo Early Translational III Molecules to Correct Aberrant RNA Signature in Human Diseased Neurons $1,654,830 University of Southern California Songtao Shi New Faculty I Oral and Craniofacial Reconstruction Using Mesenchymal Stem Cells $3,428,464 University of California, Los Angeles Noriyuki Kasahara SEED Grant Down-Regulation of Alloreactive Immune Responses to hES Cell-Derived Graft Tissues $469,219 Cedars-Sinai Medical Center Barry Stripp Research Leadership 12 Epithelial progenitors and the stromal niche as therapeutic targets in lung disease $4,841,830 University of California, Berkeley David Schaffer Tools and Technologies II Engineering Defined and Scaleable Systems for Dopaminergic Neuron Differentiation of hPSCs $1,493,928 Children's Hospital of Orange County Philip Schwartz Early Translational III Immune-Matched Neural Stem Cell Transplantation for Pediatric Neurodegenerative Disease $5,509,978 Stanford University Garry Nolan Basic Biology II Kinase signaling analysis of iPS cell reprogramming and differentiation $1,447,956 University of California, Davis Nancy Lane Disease Team Therapy Planning I Increasing the endogenous mesenchymal stem cells to the bone surface to treat osteoporosis $110,000 University of California, San Diego Shyni Varghese New Faculty II A Novel Microenvironment-Mediated Functional Skeletal Muscle from Human Embryonic Stem Cells and their In Vivo Engraftment $2,300,569 The Salk Institute for Biological Studies Samuel Pfaff SEED Grant Gene regulatory mechanisms that control spinal neuron differentiation from hES cells. $807,749 University of Southern California David Woodley Disease Team Planning Clinical Regenerative Wound Healing With Stem Cells $42,574 University of Southern California Robert Maxson Research Training II CIRM Stem Cell Biology Training Program $6,162,053 Stanford University Anne Brunet Basic Biology IV Energy metabolism and aging pathways in human stem cell reprogramming and differentiation $1,414,044 The J. David Gladstone Institutes Deepak Srivastava Basic Biology III Mechanisms of Direct Cardiac Reprogramming $1,708,560 The Jackson Laboratory West Pali Kaur Early Translational I Mouse Models for Stem Cell Therapeutic Development $3,841,240 University of California, San Francisco Emmanuelle Passegue New Faculty II Mechanisms Underlying the Responses of Normal and Cancer Stem Cells to Environmental and Therapeutic Insults $2,274,368 University of California, San Diego Shu Chien SEED Grant Combinatorial Platform for Optimizing Microenvironments to Control hESC Fate $638,140 Sanford-Burnham Medical Research Institute Mark Mercola Disease Team Planning "Stem Cell Therapies for Heart Failure" $53,150 University of California, San Francisco Linda Giudice Shared Labs Shared Research and Teaching Laboratory: a Non-Federal Human Embryonic Stem Cell Resource for the Bay Area Community $5,546,877 California State University, Channel Islands Ching-Hua Wang Bridges Curriculum Development and Implementation of Stem Cell Technology and Laboratory Management Emphasis in an Established MS Biotechnology and Bioinformatics Program at (REDACTED) and Co-development of a GE Course on Stem Cel $3,614,553 University of California, San Diego Catriona Jamieson Early Translational II Preclinical development of a pan Bcl2 inhibitor for cancer stem cell directed therapy $3,341,758 Cedars-Sinai Medical Center Terrence Town Transplantation Immunology Role of HLA in neural stem cell rejection using humanized mice $1,472,634 University of California, San Francisco Harold Bernstein Comprehensive Grant Modeling Myocardial Therapy with Human Embryonic Stem Cells $2,229,140 University of California, Irvine Lisa Flanagan Tools and Technologies I Novel Separation of Stem Cell Subpopulations $871,627 University of California, San Francisco Long-cheng Li New Cell Lines Induction of pluripotent stem cells by small RNA-guided transcriptional activation $1,375,144 University of California, San Francisco Susan Fisher Training Grant I-1 Training Grant I $3,620,652 Beckman Research Institute of City of Hope Karen Aboody Disease Team Research I Stem Cell-mediated Therapy for High-grade Glioma: Toward Phase I-II Clinical Trials $18,015,429 StemCells, Inc. Alexandra Capela Disease Team Therapy Development - Research Restoration of memory in Alzheimer’s disease: a new paradigm using neural stem cell therapy $20,000,000 Sanford-Burnham Medical Research Institute Mark Mercola Training Grant I-2 Burnham Institute CIRM Stem Cell Training Grant (Type II) $1,489,640 University of California, Berkeley Steven Conolly Tools and Technologies I Magnetic Particle Imaging: A Novel Ultra-sensitive Imaging Scannerfor Tracking Stem Cells In Vivo $882,430 Sanford-Burnham Medical Research Institute Huei-sheng Chen SEED Grant Development of Neuro-Coupled Human Embryonic Stem Cell-Derived Cardiac Pacemaker Cells. $744,639 Stanford University Alan Cheng New Faculty Physician Scientist Enhancing hair cell regeneration in mouse and human inner ear $3,266,595 University of California, Los Angeles Richard Gatti Tools and Technologies II Use of hiPSCs to develop lead compounds for the treatment of genetic diseases $1,833,054 Beckman Research Institute of City of Hope Jiing-Kuan Yee Basic Biology III Use of human iPS cells to study spinal muscular atrophy $1,268,868 University of Southern California Wange Lu Basic Biology I Defining the molecular mechanisms of somatic cell reprogramming $1,468,360 University of California, San Francisco Arnold Kriegstein Early Translational III Human ES cell-derived MGE inhibitory interneuron transplantation for spinal cord injury $1,623,251 Beckman Research Institute of City of Hope Tiziano Barberi New Faculty I Skeletal muscle development from hESC and its in vivo applications in animal models of muscular dystrophy $1,623,064 University of California, San Francisco Heike Daldrup-Link SEED Grant Labeling of human embryonic stem cells with iron oxide nanoparticles and fluorescent dyes for a non-invasive cell depiction with MR imaging and optical imaging $251,088 The J. David Gladstone Institutes Kevin Parker Research Leadership 12 Engineering Cardiac Tissue for Regeneration and Drug Development $7,480,036 University of California, Los Angeles Martin Martin Tools and Technologies II Pluripotent and Somatic Stem Cell Models to Study Inherited Diarrheal Disorders $1,783,250 University of California, Davis Kyriacos Athanasiou Early Translational III Tissue engineered cartilage from autologous, dermis-isolated, adult, stem (DIAS) cells $1,735,703 University of California, Irvine Aileen Anderson Basic Biology II Role of the microenvironment in human iPS and NSC fate and tumorigenesis $1,284,921 Cedars-Sinai Medical Center Dan Gazit Disease Team Therapy Planning I Genetically Engineered Mesenchymal Stem Cells for the Treatment of Vertebral Compression Fractures. $109,743 University of California, San Francisco Robert Blelloch New Faculty II Mechanisms of small RNA regulation in early embryonic development $3,204,897 University of California, Los Angeles Michael Teitell SEED Grant Role of Mitochondria in Self-Renewal Versus Differentiation of Human Embryonic Stem Cells $635,024 University of California, San Francisco Jeffrey Lotz Disease Team Planning A CIRM Disease Team for the Repair of Traumatically Injured and Arthritic Cartilage $55,000 Sanford-Burnham Medical Research Institute Mark Mercola Research Training II Type III CIRM Stem Cell Research Training Program $2,856,694 Stanford University Michael Cleary Basic Biology IV Prostaglandin pathway regulation of self-renwal in hematopoietic and leukemia stem cells $1,244,455 University of California, San Diego Eugene Yeo Basic Biology III Neural and general splicing factors control self-renewal, neural survival and differentiation $1,372,660 The Parkinson's Institute J. William Langston Early Translational I Using patient-specific iPSC derived dopaminergic neurons to overcome a major bottleneck in Parkinson's disease research and drug discovery $3,701,766 University of Southern California Qilong Ying New Faculty II Mechanisms Underlying the Diverse Functions of STAT3 in Embryonic Stem Cell Fate Regulation $2,413,650 The Salk Institute for Biological Studies Senyon Choe SEED Grant A method to maintain and propagate pluripotent human ES cells $796,348